Yucca Root For Arthritis Inflammation & Gout
Yucca Root reduces inflammation and relieves joint pain due to arthritis, gout and rheumatism.
Yucca Root is a supplement often used for conditions such as hip dysplasia, bone/joint problems, and soft tissue swellings. Research from the National Arthritis Medical Center states that yucca is effective for a number of types of arthritis, including gout. Yucca contains a high level of steroid saponins (natural glucosides). Saponin is a natural pain killer and is the precursor to cortisone.
YUCCA, commonly known as Spanish Dagger and Spanish Bayonet, is reputed in western herbal tradition to support joints and blood sugar problems. It was also a popular food to the American Indians. Much of the interest in Yucca surrounds steroid saponins found in the Yucca plant's stalk and root.
Yucca contains moderate amounts of calcium, sodium, zinc and B complex vitamins. It also contains small amounts of iron, magnesium, manganese, potassium, phosphorus, selenium, silicon, vitamin A and C and niacin.
Benefits of YUCCA:
• Contains the anti stress agent steroid saponins
• Reduces toxins in the alimentary canal, which helps relieve problems such as asthma, arthritis and migraine headaches
• Helps with digestion
FH-46-5 Yucca Root 450mg 100 capsules $11.95
For additional arthritis support we have several other excellent supplements:
Omega 3 Fish Oil
Glucosamine Sulfate Complex
Hyaluronic Acid with MSM
Arthritis Relief Formula
Inflammation Free for Arthritis Pain
We have organized Femhealth products into the following categories: Adaptogens, Anti-Aging, Aromatherapy Blends, Brain Boosters, Chinese Formulas, Cleansing, Eucalyptus Oil, For Women, Green Food, Herbal Formulas, Natural Medicine, Liquid Extracts, Magnetic Jewelry, Minerals, Pain Relief, Sexual Health, Single Herbs, Sports Nutrition, Vitamins, and Weight Loss.
For an alphabetical list of Femhealth products, visit our Site Directory.
PR Cheeke,1,2 S Piacente,3 and W Oleszek4
1Department of Animal Sciences, Oregon State University, Corvallis, OR 97333, USA
2Desert King International, 7024 Manya Circle, San Diego, CA 92154, USA
3Department of Pharmaceutical Sciences, University of Salerno, via Ponte Don Melillo-84084, Fisciano, Salerno, Italy
4Department of Biochemistry, Institute of Soil Science and Plant Cultivation, ul. Czartoryskich 8, 24100 Pulawy, Poland
Yucca schidigera is a medicinal plant native to Mexico. According to folk medicine, yucca extracts have anti-arthritic and anti-inflammatory effects. The plant contains several physiologically active phytochemicals. It is a rich source of steroidal saponins, and is used commercially as a saponin source. Saponins have diverse biological effects, including anti-protozoal activity. It has been postulated that saponins may have anti-arthritic properties by suppressing intestinal protozoa which may have a role in joint inflammation. Yucca is also a rich source of polyphenolics, including resveratrol and a number of other stilbenes (yuccaols A, B, C, D and E). These phenolics have anti-inflammatory activity. They are inhibitors of the nuclear transcription factor NFkappaB. NFkB stimulates synthesis of inducible nitric oxide synthase (iNOS), which causes formation of the inflammatory agent nitric oxide. Yucca phenolics are also anti-oxidants and free-radical scavengers, which may aid in suppressing reactive oxygen species that stimulate inflammatory responses. Based on these findings, further studies on the anti-arthritic effects of Yucca schidigera are warranted.
Yucca schidigera is an herbaceous plant of the lily family, native to the deserts of the south-western United States and northern Mexico. This plant was used in traditional medicine by Native Americans to treat a variety of ailments including arthritis. Yucca products are currently used in a number of applications. Yucca powder and yucca extract are used as animal feed additives, as discussed in detail by Cheeke and Otero . Beneficial effects in livestock and poultry production include: increased growth rate and improved feed conversion efficiency, reduction in atmospheric ammonia in confinement animal and poultry facilities, anti-protozoal and nematocidal activity, modification of ruminal microbe populations, inhibition of Gram-positive bacteria, reductions in stillbirths in swine, reduction in egg and tissue cholesterol contents, and anti-arthritic activity in horses and dogs. Other applications include the use of yucca extract as a foaming agent in beverages, and use in crop production as nematode and fungi-control agents, as a soil wetting agent, and crop growth stimulant. Yucca products have GRAS status, so are FDA-approved for use in humans.
Yucca contains a number of phytochemicals which contribute to these effects. The best known are the steroidal saponins. Saponins are natural detergents  that form stable foams. Saponins contain a lipophilic nucleus (the sapogenin) and one or more side chains of hydrophilic carbohydrate (Fig. 1). Thus the intact saponin molecule is a surfactant, with both fat-soluble and water-soluble moities. It has been known for many years  that saponins form insoluble complexes with cholesterol. The hydrophobic portion of the saponin (the aglycone or sapongenin) associates (lipophilic bonding) with the hydrophobic sterol nucleus of cholesterol in a stacked micellar aggregation .
Interactions of saponins with cholesterol and other sterols account for many of their biological effects, particularly those involving membrane activity. It was demonstrated more than 45 years ago that dietary saponin reduces blood cholesterol levels [5,6]. This effect is a result of the saponins binding to cholesterol excreted in bile, thus inhibiting entero-hepatic cholesterol recycling. Dietary yucca extracts lower total and LDL cholesterol levels in hypercholesterolemic humans . Saponins affect the permeability of intestinal cells by forming complexes with cholesterol in mucosal cell membranes . In a similar manner, saponins have anti-protozoal activity by complexing with cholesterol in protozoal cell membranes, causing damage to the integrity of the membrane, and cell lysis. This has been well demonstrated with rumen protozoa in vivo [9-11]; and in vitro [12,13]. The antiprotozoal (cholesterol-binding) activity requires the intact saponin structure with both nucleus and side chain present.
Protozoal diseases in which part of the life cycle occurs in the gastrointestinal tract respond to the anti-protozoal activity of saponins. For example, yucca saponins are as effective as the drug metronidazole in killing tropozoites of Giardia lamblia in the intestine . Yucca schidigera contains as much as 10% of steroidal saponins in its stem dry matter, making this plant one of the richest commercial sources of saponins. Acid hydrolysed fractions of yucca contain both furostanol and spirostanol aglycones. These include sarsapogenin, markogenin, smilagenin, samogenin, gitogenin and neogitogenin . In the plant they can be found in a multi-component mixture of glycosides [16,17]. They can be found both as monodesmosides with one sugar chain attached at 3-O- and bidesmosides with two sugar chains at 3-O- and 26-O- positions (Fig. 1). Tanaka and co-workers identified as many as 13 structurally different saponins, but all of them were monodesmosides, given trivial names YS-I-XIII . In the work of Oleszek and co-workers, eight individual saponins were isolated and identified out of which five were known spirostanol and three new furostanol structures . However, monodesmosides made up about 93% of total saponins present.
Recently it has been recognized that yucca contains other physiologically-active constituents, particularly polyphenols. Two stilbenes, including trans-3,3',5,5'-tetrahydroxy-4'-methoxystilbene and trans-3,4',5-tetraxydroxystilbene (resveratrol) were identified in yucca bark. Also, some unique compounds with spiro confirmation were isolated and characterized. These included the spirobiflavonoid, larixinol, biosynthesized by combining two C15 units of flavonoid origin, previously identified in Larix gmelini and a number of novel spirostructures, which were given trivial names of yuccaols A-E [18,19] (Fig. 2). These compounds are composed of a C15 unit probably originating from the flavonoid skeleton and a C14 stilbenic compound linked via -lactone ring. Resveratrol makes up the stilbenic portion of yuccaols A and B and trans-3,3',5,5'-tetrahydroxy-4'-methoxystilbene is the stilbene in yuccaols C, D and E. By the analogy to the biosynthesis of larixinol it was presumed that most probably these compounds are synthesized by the attachment of the stilbenic derivative to the carbocationic intermediate occurring during the oxidation of flavanone to flavanol and subsequent rearrangement of this intermediate. Resveratrol was identified previously in grapes and is believed to be a phytoalexin produced by the plant to fight fungal colonization . In yucca, this compound as well as its methoxyderivative and yuccaols can be found exclusively in yucca bark (Table 1), which is a dead tissue; it is not clear how these compounds are accumulated in this plant organ. Since yucca bark is a component of commercially available yucca powder, these compounds are present exclusively in this product; they are not present in yucca extract obtained by mechanical extraction.
The chemistry and bioactivity of yucca saponins and phenolics have recently been reviewed by Piacente et al. .
Yucca products have been used for many years for reputed anti-arthritic effects, both by Native Americans and more recently by the nutraceutical industry. Whole yucca plant powder in tablet form is a common nutraceutical. The only direct studies of anti-arthritic effects of yucca are those of Bingham [22-24], who reported that symptoms of pain and swelling in arthritic human patients were relieved by consumption of yucca tablets. Bingham's work was reported in an obscure journal, and has apparently not been recognized as valid by the arthritis research community. Nevertheless, Bingham's reports have led to the widespread use of yucca products for treatment and prevention of arthritis not only in humans but also in horses and dogs.
Bingham  proposed that yucca saponins have anti-protozoal activity, which suppresses protozoal infection of the intestine. Bingham  reported that R. Wyburn-Mason had observed a free-living protozoan, Naegleria, universally present in the joints of arthritic patients . Tropozoites of the organism reportedly were found in the intestine. Support for this theory was provided by the effectiveness of metronidazole, an anti-protozoal drug, in arthritis treatment. Saponins are also effective anti-protozoal agents. Yucca saponins are as effective as metronidazole in killing giardia tropozoites in the intestine . Thus, if the protozoal theory of causation of arthritis has any merit, a role of yucca in arthritis treatment can be advanced on the basis of the anti-protozoal activity of yucca saponins.
There are well-known interactions between rheumatoid arthritis, chronic inflammatory disease, and food and nutrition [26,27]. Of particular importance are nutrients that stimulate the formation of oxidants and peroxides (e.g. unsaturated fatty acids, iron), which promote inflammatory disease, and antioxidants (e.g. vitamin E) and omega-3 fatty acids, which protect against auto-oxidation. Yucca compounds may have roles in these effects. Yucca polyphenols are potent antioxidants [18,21,28]. Yucca saponins are known to reduce iron absorption  and may reduce fatty acid absorption by sequestering bile acids necessary for micelle formation and fat absorption .
Cordain  stated, "Despite the almost universal clinical observation that inflammation of the gut is frequently associated with inflammation of the joints and vice-versa, the nature of the relationship remains elusive." These authors reported that arthritis is associated with intestinal bacterial overgrowth of Escherichia coli and Lactobacillus lactis. Yucca saponins have antibacterial properties [31,32], although Lactobacillus spp. and E. coli may be tolerant of yucca extract and yucca saponins . Thus, a beneficial effect of yucca on arthritis could involve anti-protozoal, anti-oxidant and anti-bacterial activities. As previously mentioned, the drug metronidazole attenuates gastrointestinal inflammation and can prevent activation of arthritis in animal models . Yucca saponins are as effective as metronidazole in control of intestinal protozoa .
Recent research suggests another possible mode of action of yucca in preventing arthritis by anti-inflammatory activity. Yucca contains anti-inflammatory polyphenolics such as resveratrol and yuccaols A, B, C, D and E [18,19]. Yucca bark and whole yucca plant powder contain resveratrol (Table 1), well known for its anti-inflammatory activity [20,33]. Marzocco  demonstrated that yuccaols inhibit inducible nitric oxide synthase (iNOS) expression (Fig. 3). Nitric oxide is an inflammatory agent, and its content in tissues increases during inflammatory responses. The expression of iNOS is controlled by NFkappaB (NFkB), a transcription factor that regulates gene expression. Resveratrol and yucca phenolics strongly inhibit NFkB . Yuccaol C is particularly effective (Fig. 3 and 4). Thus, whole plant yucca powder has powerful anti-inflammatory activity, mediated via inhibition of NFkB activation.
The generation of reactive oxygen species (free radicals) is an important factor in the development and maintenance of rheumatoid arthritis in humans and animal models . One source of free radicals is nitric oxide produced within the synoviocytes and chondrocytes, giving rise to the highly toxic radical peroxynitrite . The study of experimental arthritis in animals has demonstrated an increased activity of iNOS [36,37]. Thus the NFkB inhibitory and anti-oxidant effects of yucca polyphenolics may aid in prevention of reactive oxygen species (ROS) induction of arthritis by inhibiting the induction of iNOS.
Platelet aggregation is characteristic of inflammation. Yucca phenolics have inhibitory activity against platelet aggregation [38-40]. Yucca phenolics also have antioxidant activity  and free-radical scavenging effects . Blood platelets participate in allergic inflammation responses . Yuccaols inhibit the generation of free radicals in blood platelets . One of the yucca phenolics, trans-3,3',5,5'-tetrahydroxy-4-methoxystilbene, showed the highest anti-platelet action.
Another botanical product with anti-inflammatory activity is cat's claw . As reviewed by Miller et al. , cat's claw (Uncaria guianensis) "is a remarkably potent inhibitor of NFkB activity and tumor necrosis factor production." Evaluation of the anti-inflammatory activity of a combination of yucca and cat's claw would be of interest.
The evidence presented in this review indicates that yucca has potential in vivo anti-inflammatory activity, and warrants more in-depth investigation.
Yucca schidigera is a medicinal plant which may have beneficial effects in the prevention and treatment of arthritis. Active components of yucca include steroidal saponins and polyphenolics such as resveratrol and yuccaols. Saponins may have anti-arthritic effects associated with their anti-protozoal activity. Yucca polyphenolics may have several roles in anti-arthritic activity. They inhibit NFkB, a transcription factor which stimulates iNOS, an inducible enzyme which produces the inflammatory agent nitric oxide. Yucca phenolics also are antioxidants and free-radical scavengers, which may aid in suppressing reactive oxygen species (ROS) that stimulate inflammatory responses. Folk medicine and anecdotal reports suggest that whole yucca plant powder aids in prevention and treatment of arthritis. Further studies on the anti-arthritic effects of yucca are warranted.
1. Cheeke, PR.; Otero, R. Yucca, quillaja may have role in animal nutrition. Feedstuffs. 2005. pp. 11–14.http://www.feedstuffs.com/ME2/Default.asp
2. Cheeke, PR. Natural Toxicants in Feeds, Forages and Poisonous Plants. Upper Saddle River, NJ: Prentice-Hall; 1998.
3. Lindhal, IL.; Shalkop, WT.; Dougherty, RW.; Thompson, CR.; Van Atta, GR.; Bickoff, EM.; Walter, ED.; Livingston, AG.; Guggolz, J.; Wilson, RH.; Sideman, MB.; DeEds, F. USDA Technical Bulletin No 1161. Washington, D.C; 1957. Alfalfa saponins: Studies on their chemical, pharmacological and physiological properties in relation to ruminant bloat.
4. Oakenfull, D.; Sidhu, GS. Saponins. In: Cheeke PR. , editor. Toxicants of Plant Origin. Vol. 2. Boca Raton, Fla: CRC Press; 1989. pp. 97–141.
5. Newman HA, Kummerow FA, Scott HH. Dietary saponin, a factor which may reduce liver and serum cholesterol levels. Poult Sci. 1957;37:42–46.
6. Griminger P, Fisher H. Dietary saponin and plasma cholesterol in the chicken. Proc Soc Exp Biol Med. 1958;99:424–426. [PubMed]
7. Kim S-W, Park S-K, Kang S-I, Kang H-C, Oh H-J, Bae C-Y, Bae D-H. Hypocholesterolemic property of Yucca schidigera and Quillaja saponaria extracts in human body. Arch Pharm Res. 2003;26:1042–1046. [PubMed]
8. Johnson IT, Gee JM, Price KR, Curl C, Fenwick GR. Influence of saponins on gut permeability and active nutrient transport in vitro. J Nutr. 1986;116:2270–2277. [PubMed]
9. Lu CD, Jorgensen NA. Alfalfa saponins affect site and extent of nutrient digestion in ruminants. J Nutr. 1987;117:919–927. [PubMed]
10. Wallace RJ, Arthaud L, Newbold CJ. Influence of Yucca schidigera extract on ruminal ammonia concentrations and ruminal microorganisms. Appl Environ Microbiol. 1994;60:1762–1767. [PubMed]
11. Klita PT, Mathison GW, Fenton TW, Hardin RT. Effects of alfalfa root saponins on digestive function in sheep. J Anim Sci. 1996;74:1144–1156. [PubMed]
12. Makkar HPS, Sen S, Blummel M, Becker K. Effects of fractions containing saponins from Yucca schidigera, Quillaja saponaria and Acacia auriculoformis on rumen fermentation. J Agric Food Chem. 1998;46:4324–4328. doi: 10.1021/jf980269q.
13. Wang Y, McAllister TA, Newbold CJ, Rode LM, Cheeke PR, Cheng K-J. Effects of Yucca schidigera extract on fermentation and degradation of steroidal saponins in the rumen simulation technique (RUSITEC). Anim Feed Sci Tech. 1998;74:143–153. doi: 10.1016/S0377-8401(98)00137-0.
14. McAllister TA, Annett CB, Cockwill CL, Olson ME, Yang Y, Cheeke PR. Studies on the use of Yucca schidigera to control giardiasis. Vet Parasit. 2001;97:85–99. doi: 10.1016/S0304-4017(01)00394-6.
15. Kaneda N, Nakanishi H, Staba J. Steroidal constituents of Yucca schidigera plants and tissue cultures. Phytochemistry. 1987;26:1425–1429. doi: 10.1016/S0031-9422(00)81827-0.
16. Tanaka O, Ikeda T, Ohtani K, Kasai R, Yamasaki K. Antiyeast steroidal saponins from Yucca schidigera (Mohave Yucca), a new anti-food-deteriorating agent. J Nat Prod. 2000;63:332–338. doi: 10.1021/np990394b. [PubMed]
17. Oleszek W, Sitek M, Stochmal A, Piacente S, Pizza C, Cheeke P. Steroidal saponins of Yucca schidigera Roezl. J Agric Food Chem. 2001;49:4392–4396. doi: 10.1021/jf010598+. [PubMed]
18. Oleszek W, Sitek M, Stochmal A, Piacente S, Pizza C, Cheeke P. Resveratrol and other phenolics from the bark of Yucca schidigera Roezl. J Agric Food Chem. 2001;49:747–752. doi: 10.1021/jf001056f. [PubMed]
19. Piacente S, Montoro P, Oleszek W, Pizza C. Yucca schidigera bark: Phenolic constituents and antioxidant activity. J Nat Prod. 2004:882–885. doi: 10.1021/np030369c. [PubMed]
20. Bertelli AA, Migliori M, Panichi V, Origlia C, Das FilippiDK, Giovannini L. Resveratrol, a component of wine and grapes, in the prevention of kidney disease. Ann NY Acad Sci. 2002;957:230–238. [PubMed]
21. Piacente S, Pizza C, Oleszek W. Saponins and phenolcs of Yucca schidigera Roezl: Chemistry and bioactivity. Phytochem Rev. 2005;4:177–190. doi: 10.1007/s11101-005-1234-5.
22. Bingham R. New and effective approaches to the prevention and treatment of arthritis. J Appl Nutr. 1976;28:38–47.
23. Bingham R, Bellow BA, Bellow JG. Yucca plant saponin in the management of arthritis. J Appl Nutr. 1975;27:45–51.
24. Bingham R, Harris DH, Laga T. Yucca plant saponin in the treatment of hypertension and hypercholesterolemia. J Appl Nutr. 1978;30:127–136.
25. Wyburn-Mason R. Naegleria in rheumatoid and malignant disease. SA Med J. 1983;63:31.
26. Parke AL, Parke DV, Jones FA. Diet and nutrition in rheumatoid arthritis and other chronic inflammatory diseases. J Clin Biochem Nutr. 1996;20:1–26.
27. Martin RH. The role of nutrition and diet in rheumatoid arthritis. Proc Nutr Soc. 1998;57:231–234. doi: 10.1079/PNS19980036. [PubMed]
28. Oleszek, W.; Sitek, M.; Stochmal, A.; Cheeke, P. Antioxidant properties of Yucca schidigera products. In: Pfannhauser W, Fenwick GR, Khokhar S. , editor. Biologically-active Phytochemicals in Food Analysis, Metabolism, Bioavailability and Function. Royal Society of Chemistry; 2001. pp. 303–306.
29. Southon S, Wright AJA, Price KR, Fairweather-Tait SJ, Fenwick GR. The effect of three types of saponin on iron and zinc absorption from a single meal in the rat. Brit J Nutr. 1988;59:389–396. doi: 10.1079/BJN19880048. [PubMed]
30. Cordain L, Toohey L, Smith MJ, Hickey MS. Modulation of immune function by dietary lectins in rheumatoid arthritis. Brit J Nutr. 2000;83:207–217. [PubMed]
31. Katsunuma Y, Nakamura Y, Toyoda A, Minato H. Effect of Yucca schidigera extract and saponins on growth of bacteria isolated from animal intestinal tract. Anim Sci. 2000;71:64–170.
32. Wang Y, McAllister TA, Yanke L-J, Cheeke PR. Effect of steroidal saponin from Yucca schidigera extract on ruminal microbes. J Appl Microbiol. 2000;88:887–896. doi: 10.1046/j.1365-2672.2000.01054.x. [PubMed]
33. Bhat KP, Pezzuto JM. Cancer chemopreventive activity of resveratrol. Ann NY Acad Sci. 2002;957:210–229. [PubMed]
34. Marzocco S, Piacente S, Pizza C, Oleszek W, Stochmal A, Pinto A, Sorrentino R, Autore G. Inhibition of inducible nitric oxide synthase expression by yuccaol C from Yucca schidigera roezl. http://www.sciencedirect.comLife Sci. 2004;75:1491–1501. doi: 10.1016/j.lfs.2004.03.013. [PubMed]
35. Darlington LG, Stone TW. Antioxidants and fatty acids in the amelioration of rheumatoid arthritis and related disorders. Brit J Nutr. 2001;85:251–269. [PubMed]
36. McCartney-Francis N, Allen JB, Mixel DE, Xie Q-W, Nathan CF. Suppression of arthritis by an inhibitor of nitric oxide synthase. J Exp Med. 1993;178:749–754. doi: 10.1084/jem.178.2.749. [PubMed]
37. Sakurai HG, Kohsaka H, Liu M-F, Higashiyama H, Hirata Y, Kanno K, Saito I, Miyasaka N. Nitric oxide production and inducible nitric oxide synthase expression in inflammatory arthritides. J Clin Investigation. 1995;96:2357–2363.
38. Olas B, Wachowicz B, Stochmal A, Oleszek W. Anti-platelet effects of different phenolic compounds from Yucca schidigera roezl. bark. Platelets. 2002;13:167–173. doi: 10.1080/09533710022149386. [PubMed]
39. Olas B, Wachowicz B, Stochmal A, Oleszek W. Inhibition of oxidative stress in blood platelets by different phenolics from Yucca schidigera roezl. bark. Nutrition. 2003;19:633–640. doi: 10.1016/S0899-9007(03)00036-4. [PubMed]
40. Olas B, Wachowicz B, Stochmal A, Oleszek W. Inhibition of blood platelet adhesion and secretion by different phenolics from Yucca schidigera Roezl. bark. Nutrition. 2005;21:199–206. doi: 10.1016/j.nut.2004.03.024. [PubMed]
41. Levy-Toledano S. Platelet signal transduction pathways: could we organize them into a hierarchy? Haemostasis. 1999;29:4–15. doi: 10.1159/000022456. [PubMed]
42. Miller MJS, Mehta K, Kunte S, Raut V, Gala J, Dhumale R, Shukla A, Tupalli H, Parikh H, Bobrowski P, Chaudhary J. Early relief of osteoarthritis symptoms with a natural mineral supplement and a herbomineral combination: A randomized controlled trial [ISRCTN38432711]. J Inflammation. 2005;2:11. doi: 10.1186/1476-9255-2-11.
J Inflamm (Lond). 2006; 3: 6.
Published online 2006 March 29. doi: 10.1186/1476-9255-3-6.
Copyright © 2006 Cheeke et al; licensee BioMed Central Ltd.
| Hydroxy Tryptophan | Glucosamine Complex | Inflammation Free | Pain Formula | Valerian Root | Yucca | Hyaluronic Acid | CMO Pain Cream |
| Anti-Aging | Brain Boosters | Chinese Formulas | Cleansing | Essential Oils | For Women | Green Food | Herbal Formulas | Natural Medicine | Libido Boosters | Liquid Extracts | Minerals | Pain Relief | Single Herbs | Sports Nutrition | Vitamins | Weight Loss | Adaptogens | Hot Tub Maintenance |
| Return Home | Jewelry | Skin Care | Femhealth Products | Great Links | Health Conditions | Contact Us | Cholesterol Control | Site Directory |